Statins are diabetogenic – Myth or reality?

Sattar, N. and Taskinen, M.-R. (2013) Statins are diabetogenic – Myth or reality? Atherosclerosis Supplements, 13(1), pp. 1-10. (doi:10.1016/j.atherosclerosissup.2012.06.001)

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Abstract

Multiple clinical trials have demonstrated the beneficial effects of statins in lowering levels of low-density lipoprotein and in the prevention of cardiovascular disease. However, although statins have a good safety profile, a debate has been ongoing as to whether use of statins increases risk of new-onset diabetes. Recent large scale meta-analyses of statin trials support the concept of a diabetogenic effect of statins, as do some other small trials assessing changes in glycaemia parameters and insulin levels. However, a definitive mechanism of action has not yet been elucidated. Nevertheless, the level of evidence has been sufficient to lead the FDA to make a change to the labelling of statins. This review assesses the current available evidence and offers a clinical perspective.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sattar, Professor Naveed
Authors: Sattar, N., and Taskinen, M.-R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Atherosclerosis Supplements
Publisher:Elsevier
ISSN:1567-5688
Published Online:19 July 2012

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