Nicotinic α4β2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations

O’Brien, J. T., Colloby, S. J., Pakrasi, S., Perry, E. K., Pimlott, S. L. , Wyper, D. J., McKeith, I. G. and Williams, E. D. (2008) Nicotinic α4β2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations. NeuroImage, 40(3), pp. 1056-1063. (doi: 10.1016/j.neuroimage.2008.01.010) (PMID:18295510))

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Abstract

<p>Introduction To investigate in vivo differences in the distribution of α4β2 subtypes of nAChR using the ligand <sup>123</sup>I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) and single photon emission computed tomography (SPECT) in DLB and similarly aged controls.</p> <p>Methods Thirty-one subjects (15 DLB and 16 controls) underwent <sup>123</sup>I-5IA-85380 and perfusion (<sup>99m</sup>Tc-exametazime) SPECT scanning. Patient scans were compared to scans of control subjects on a voxel-by-voxel basis using SPM2.</p> <p>Results Compared to controls, significant reductions in relative <sup>123</sup>I-5IA-85380 uptake were identified in frontal, striatal, temporal and cingulate regions in DLB. Elevation of scaled <sup>123</sup>I-5IA-85380 uptake in occipital cortex was observed in DLB relative to controls, as well as being associated with DLB subjects with a recent history of visual hallucinations. Changes in <sup>123</sup>I-5IA-85380 SPECT in DLB were different from perfusion.</p> <p>Conclusion: Reductions in normalised <sup>123</sup>I-5IA-85380 uptake in DLB were distinct from their perfusion deficits. Significant increase in occipital lobe uptake was present in DLB, a change most pronounced in subjects with a recent history of visual hallucinations. The findings directly link cholinergic changes in occipital lobe to visual hallucinations in DLB.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pimlott, Dr Sally and Wyper, Professor David
Authors: O’Brien, J. T., Colloby, S. J., Pakrasi, S., Perry, E. K., Pimlott, S. L., Wyper, D. J., McKeith, I. G., and Williams, E. D.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:NeuroImage
Publisher:Elsevier Inc.
ISSN:1053-8119
ISSN (Online):1095-9572
Published Online:19 January 2008

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