A mathematical model of the human respiratory system during exercise

Thamrin, H. and Murray-Smith, D.J. (2009) A mathematical model of the human respiratory system during exercise. In: IASTED International Conference on Modelling, Simulation and Identification (MSI 2009), Beijing, China, 12-14 Oct 2009,

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Abstract

This paper describes a respiratory control system model and the associated computer simulations for human subjects during incremental exercise, involving work rates from zero up to the highest level in the heavy exercise domain. Modelling the respiratory control system for conditions above lactate threshold has rarely been attempted because many subsystems begin to lose proportionality in their responses. Our model is built on the basis of putative mechanisms and is based on information identified from a large body of published work. Simulation results are presented and validated using experimental results from published sources. The model confirms that the human body employs an open-loop control strategy for ventilation during exercise, which contrasts with the negative feedback control mode employed for the rest condition. It is suggested that control of ventilation simultaneously involves at least two variables, one being proportional to the pulmonary CO2 output and another being proportional to blood acidity.

Item Type:Conference Proceedings
Keywords:Biomedical modelling, respiratory control system, exercise, simulation.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Murray-Smith, Professor David
Authors: Thamrin, H., and Murray-Smith, D.J.
Subjects:Q Science > QA Mathematics > QA75 Electronic computers. Computer science
R Medicine > R Medicine (General)
T Technology > TJ Mechanical engineering and machinery
T Technology > TK Electrical engineering. Electronics Nuclear engineering
College/School:College of Science and Engineering > School of Engineering
Copyright Holders:Copyright © 2009 The Authors
Publisher Policy:Reproduced in accordance with the copyright policy of the conference organisers.

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