Altered excitation-contraction coupling in human chronic atrial fibrillation

Grandi, E., Workman, A.J. and Pandit, S.V. (2012) Altered excitation-contraction coupling in human chronic atrial fibrillation. Journal of Atrial Fibrillation, 2(10), pp. 1-17.

Abstract

This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory period, depressed intracellular Ca²⁺ transient, and reduced myocyte contractility. Here we summarize the current knowledge of the ionic bases underlying these changes. Understanding the molecular mechanisms of excitation-contraction-coupling remodeling in the fibrillating human atria is important to identify new potential targets for AF therapy.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Workman, Dr Antony
• Authors: Grandi, E., Workman, A.J., and Pandit, S.V.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Journal of Atrial Fibrillation
• ISSN: 1941-6911
• Copyright Holders: Copyright © 2012 The Authors
• First Published: First published in Journal of Atrial Fibrillation 2(10):1-17
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher

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