LaThangue, N.B. (2005) A mismatched role for Bcl-2. Nature Cell Biology, 7(2), pp. 101-102. (doi: 10.1038/ncb0205-101)
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Abstract
Bcl-2 has previously been characterized as an anti-apoptotic protein. However, it has now been linked to DNA mismatch repair (MMR). By retaining E2F-1 in a transcriptionally inactive state, through the induction of hypophosphorylated retinoblastoma protein, Bcl-2 hinders the expression of a key component of mismatch repair, MSH2. This study could therefore help to explain the mutagenicity that is associated with Bcl-2.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | LaThangue, N.B. |
| College/School: | UNSPECIFIED |
| Journal Name: | Nature Cell Biology |
| Publisher: | Nature Publishing Group |
| ISSN: | 1465-7392 |
| ISSN (Online): | 1476-4679 |
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