Smith, L. and La Thangue, N.B. (2005) Signalling DNA damage by regulating p53 co-factor activity. Cell Cycle, 4(1), pp. 30-32. (doi: 10.4161/cc.4.1.1397)
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Abstract
In response to DNA damage the related phosphatidylinositol-3-OH-kinase-like-kinases ATM and ATR phosphorylate downstream protein targets which facilitate the DNA damage response. A new pathway in which ATM phosphorylates the transcriptional co-factor strap has been elucidated. Phosphorylation causes the stabilization of nuclear Strap and favours the formation of a stress-responsive co-activator complex. Strap activity enhances p53 acetylation, and augments the response to DNA damage. Most interestingly, in AT cells Strap remains cytoplasmic, and a mutant derivative that cannot be phosphorylated by ATM is similarly localised to the cytoplasm. These results argue that Strap is an important downstream effector in the DNA damage response.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | UNSPECIFIED |
| Authors: | Smith, L., and La Thangue, N.B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Cell Cycle |
| Publisher: | Landes Bioscience |
| ISSN: | 1538-4101 |
| ISSN (Online): | 1551-4005 |
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