Environmental toxicogenomics: a post-genomic approach to analysing biological responses to environmental toxins

Jayapal, M., Bhattacharjee, R. N., Melendez Romero, A. J. and Hande, M.P. (2010) Environmental toxicogenomics: a post-genomic approach to analysing biological responses to environmental toxins. International Journal of Biochemistry and Cell Biology, 42(2), pp. 230-240. (doi:10.1016/j.biocel.2009.10.007)

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Publisher's URL: http://dx.doi.org/10.1016/j.biocel.2009.10.007

Abstract

Environmental genomics has revolutionised how researchers can study the molecular basis of adverse effects of environmental toxicants. It is expected that the new discipline will afford efficient and high-throughput means to delineate mechanisms of action, risk assessment, identify and understand basic pathogenic mechanisms that are critical to disease progression, predict toxicity of unknown agents and to more precisely phenotype disease subtypes. Previously, we have demonstrated the potential of environmental genomics in a toxicant exposure model and, perhaps, this might become a crucial tool in biological response marker or biomarker discovery. To illustrate how toxicogenomics can be useful, we provide here an overview of some of the past and potential future aspects of environmental genomics. The present article also reviews the principles and technological concerns, and the standards and databases of toxicogenomics. In addition, applications of toxicogenomics in drug target identifications and validation strategies are also discussed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Melendez Romero, Dr Alirio
Authors: Jayapal, M., Bhattacharjee, R. N., Melendez Romero, A. J., and Hande, M.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal of Biochemistry and Cell Biology
Publisher:Elsevier
ISSN:1357-2725
ISSN (Online):1878-5875
Published Online:15 October 2009
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
462311Therapeutic potential of Sphingosine Kinase blockage in allergic anaphylaxis.Alirio Melendez RomeroMedical Research Council (MRC)G0700794Institute of Infection Immunity and Inflammation