Identification and phenotypic characterization of γδ T cells in rat lymph

Shekhar, S., Milling, S. , Jenkins, C. and MacPherson, G. (2012) Identification and phenotypic characterization of γδ T cells in rat lymph. Research in Veterinary Science, 93(1), pp. 168-171. (doi: 10.1016/j.rvsc.2011.07.014)

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γδ T cells represent an unconventional subset of T lymphocytes that are abundant in epithelial tissues and serve as an early immune defense against microbes. We have, for the first time, identified γδ T cells in steady-state thoracic duct lymph (TDL) from rats. The lymph contains γδ T cells expressing CD8 but not CD4, CD25, MHC-II or CD103. The percentage of TDL γδ T cells in rats does not change when the mesenteric lymph nodes (MLN) are surgically removed. Our data suggest that a proportion of γδ T cells migrate from the intestine into rat TDL, under steady-state conditions.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Milling, Professor Simon
Authors: Shekhar, S., Milling, S., Jenkins, C., and MacPherson, G.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Research in Veterinary Science
ISSN (Online):1532-2661
Published Online:20 August 2011
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
512511The Functions of Migrating Dendritic CellsSimon MillingMedical Research Council (MRC)G0900270Infection Immunity and Inflammation Medicine