Cerovic, V., Houston, S., Scott, C., Aumeunier, A., Yrlid, U., Mowat, A. and Milling, S. (2013) Intestinal CD103 − dendritic cells migrate in lymph and prime effector T cells. Mucosal Immunology, 6(1), pp. 104-113. (doi: 10.1038/mi.2012.53)
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Publisher's URL: http://dx.doi.org/10.1038/mi.2012.53
Abstract
Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103 − DC subsets in intestinal lymph. Similar to CD103 + DCs, these intestine-derived CD103 − DCs are responsive to Flt3 and they efficiently prime and confer a gut-homing phenotype to naive T cells. However, uniquely among intestinal DCs, CD103<sup>−</sup> CD11b<sup>+</sup> CX3CR1int lymph DCs induce the differentiation of both interferon-γ and interleukin-17-producing effector T cells, even in the absence of overt stimulation. Priming by CD103<sup>−</sup> CD11b<sup>+</sup> DCs represents a novel mechanism for the rapid generation of effector T-cell responses in the gut. Therefore, these cells may prove to be valuable targets for the treatment of intestinal inflammation or in the development of effective oral vaccines.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Aumeunier, Dr Aude and Milling, Professor Simon and Mowat, Professor Allan |
Authors: | Cerovic, V., Houston, S., Scott, C., Aumeunier, A., Yrlid, U., Mowat, A., and Milling, S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Mucosal Immunology |
ISSN: | 1933-0219 |
ISSN (Online): | 1935-3456 |
Published Online: | 20 June 2012 |
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