B-type natriuretic peptide and glycaemia: an emerging cardiometabolic pathway?

Welsh, P. and McMurray, J.J. (2012) B-type natriuretic peptide and glycaemia: an emerging cardiometabolic pathway? Diabetologia, 55(5), pp. 1240-1243. (doi:10.1007/s00125-012-2515-3)

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Publisher's URL: http://dx.doi.org/10.1007/s00125-012-2515-3

Abstract

There is emerging evidence of cross-talk between the myocardium and systemic metabolic pathways. In particular, there is interest in the potential metabolic effects of A-type and B-type natriuretic peptides (ANP and BNP), produced in the myocardial tissue in response to ventricular stretch and cardiac overload. This commentary provides an overview of the evidence that natriuretic peptides promote lipolysis and enhance adiponectin production. In addition, we review new and existing evidence that BNP may directly improve glucose control, or else lower glucose indirectly via enhanced capillary permeability or greater renal excretion. Further investigation of the links between natriuretic peptide and glycaemia would seem important given the potential to reveal novel mechanisms to treat diabetes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Welsh, Dr Paul and McMurray, Professor John
Authors: Welsh, P., and McMurray, J.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Diabetologia
Publisher:Springer-Verlag
ISSN:0012-186X
ISSN (Online):1432-0428
Published Online:08 March 2012
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
531741NT-proBNP as a predictor of vascular events in WOSCOPS: using modern epidemiological techniques to test clinical utility of a biomarkerPaul WelshBritish Heart Foundation (BHF)FS/10/005/28147Institute of Cardiovascular and Medical Sciences