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A study of protein turnover in preterm neonates using 15N enrichment of urinary ammonia

Stack, T., Reeds, P., Preston, T., Hay, S., Lloyd, D.J., and Aggett, P.J. (1990) A study of protein turnover in preterm neonates using 15N enrichment of urinary ammonia. European Journal of Clinical Nutrition, 44 (3). pp. 231-234. ISSN 0954-3007

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Abstract

Hydrolysed yeast protein labelled with 15N was used to measure protein turnover, protein synthesis and protein breakdown in preterm infants. The yeast tracer was given as a bolus intragastric dose and protein turnover was determined from the 15N enrichment of urinary ammonia over known periods of about 12 h. Six boys (birthweight less than 1500 g) with gestation of 27-35 weeks were studied either two or three times at post-natal ages ranging from 13 to 54 d. There was no significant correlation between protein turnover with increasing post-conceptional or post-natal age. There was considerable interindividual variation and reproducibility varied between different infants. We suggest that this is a convenient non-invasive technique for monitoring serially nitrogen and protein metabolism in infants and that as such it merits further assessment.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preston, Prof Thomas
Authors: Stack, T., Reeds, P., Preston, T., Hay, S., Lloyd, D.J., and Aggett, P.J.
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:European Journal of Clinical Nutrition
ISSN:0954-3007

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