Parker, A.C., Pritchard, P., Preston, T., Dalzell, A.M., and Choonara, I. (1997) Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test. British Journal of Clinical Pharmacology, 43 (5). pp. 467-470. ISSN 0306-5251 (doi:10.1046/j.1365-2125.1997.00589.x)
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Aims To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis.Methods The caffeine breath test was carried out prior to the administration of cimetidine and after 2–3 weeks therapy. The children (n=1) received 300–800 mg cimetidine daily (11–36 mg kg−1 day−1 ). Results There was no significant change in the 2 h cumulative labelled CO2 following the administration of cimetidine (mean values 5.61% before and 4.87% during cimetidine; Student’s t-test P>0.2). Conclusions Cimetidine did not have an inhibitory effect on the metabolism of caffeine in this group of children studied.
|Glasgow Author(s):||Preston, Prof Thomas|
|Authors:||Parker, A.C., Pritchard, P., Preston, T., Dalzell, A.M., and Choonara, I.|
|College/School:||College of Science and Engineering > Scottish Universities Environmental Research Centre|
|Journal Name:||British Journal of Clinical Pharmacology|
|Journal Abbr.:||Br. J. Clin. Pharmacol.|