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Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test

Parker, A.C., Pritchard, P., Preston, T., Dalzell, A.M., and Choonara, I. (1997) Lack of inhibitory effect of cimetidine on caffeine metabolism in children using the caffeine breath test. British Journal of Clinical Pharmacology, 43 (5). pp. 467-470. ISSN 0306-5251 (doi:10.1046/j.1365-2125.1997.00589.x)

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Abstract

Aims To study the potential drug interaction between cimetidine and caffeine in a group of children who received cimetidine for gastritis.

Methods The caffeine breath test was carried out prior to the administration of cimetidine and after 2–3 weeks therapy. The children (n=1) received 300–800 mg cimetidine daily (11–36 mg kg−1 day−1 ).

Results There was no significant change in the 2 h cumulative labelled CO2 following the administration of cimetidine (mean values 5.61% before and 4.87% during cimetidine; Student’s t-test P>0.2).

Conclusions Cimetidine did not have an inhibitory effect on the metabolism of caffeine in this group of children studied.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Preston, Prof Thomas
Authors: Parker, A.C., Pritchard, P., Preston, T., Dalzell, A.M., and Choonara, I.
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:British Journal of Clinical Pharmacology
Journal Abbr.:Br. J. Clin. Pharmacol.
ISSN:0306-5251
ISSN (Online):1365-2125

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