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Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test

Parker, A.C., Preston, T., Heaf, D., Kitteringham, N.R., and Choonara, I. (1994) Inhibition of caffeine metabolism by ciprofloxacin in children with cystic fibrosis as measured by the caffeine breath test. British Journal of Clinical Pharmacology, 38 (6). pp. 573-576. ISSN 0306-5251

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Abstract

The caffeine breath test was carried out in six children with cystic fibrosis, before and during a course of ciprofloxacin. There was a significant decrease in the 2 h cumulative labelled CO2 exhaled during ciprofloxacin treatment, mean difference (s.d.) -5.2(3.3)%, P < 0.02. The results suggest an inhibition of 3-N-demethylation of caffeine (CYP1A2 enzyme activity) by ciprofloxacin. Ciprofloxacin may cause significant drug interactions in children with cystic fibrosis. The caffeine breath test can be used to study drug interactions involving CYP1A2 in children.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preston, Prof Thomas
Authors: Parker, A.C., Preston, T., Heaf, D., Kitteringham, N.R., and Choonara, I.
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:British Journal of Clinical Pharmacology
Journal Abbr.:Br. J. Clin. Pharmacol.
ISSN:0306-5251
ISSN (Online):1365-2125
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