McMillan, D.C., Simpson, J.M., Preston, T., Watson, W.S., Fearon, K.C.H., Shenkin, A., Burns, H.J.G., and McArdle, C.S. (1994) Effect of megestrol acetate on weight loss, body composition and blood screen of gastrointestinal cancer patients. Clinical Nutrition, 13 (2). pp. 85-89. ISSN 0261-5614 (doi:10.1016/0261-5614(94)90065-5)
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Reduced food intake is probably the major cause of continuing weightloss in cancerpatients. Therefore, agents which stimulate food intake may be of significant benefit to such patients. To examine this, a randomized double-blind placebo controlled study of megestrolacetate was carried out. 38 gastrointestinalcancerpatients with weightloss (8–43% of pre-illness stable weight) were entered into the study. 26 were evaluable at 6 weeks and 21 at 12 weeks. Clinical details, serum biochemistry and haematology were examined at 6 and 12 weeks and total body water, total body potassium at 12 weeks after the baseline assessment. There was no significant weight change in either group over the 6 or 12 weeks. Furthermore, there was no significant difference in total body water, total body potassium, blood biochemistry or haematology between the groups over the study period. It does not appear that megestrolacetate at a dose of 480 mg/day results in weight gain in advanced gastrointestinal cancer patients with weight loss.
|Glasgow Author(s):||Preston, Prof Thomas and McMillan, Prof Donald|
|Authors:||McMillan, D.C., Simpson, J.M., Preston, T., Watson, W.S., Fearon, K.C.H., Shenkin, A., Burns, H.J.G., and McArdle, C.S.|
|College/School:||College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities|
College of Science and Engineering > Scottish Universities Environmental Research Centre
|Journal Name:||Clinical Nutrition|
|Published Online:||30 March 2004|