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Failure of systemic ketosis to control cachexia and the growth rate of the Walker 256 carcinosarcoma in rats

Fearon, K.C., Tisdale, M.J., Preston, T., Plumb, J.A., and Calman, K.C. (1985) Failure of systemic ketosis to control cachexia and the growth rate of the Walker 256 carcinosarcoma in rats. British Journal of Cancer, 52 (1). pp. 87-92. ISSN 0007-0920

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Abstract

The Walker 256 carcinosarcoma was shown to lack the enzyme 3-ketoacid CoA transferase. This suggests that ketone bodies cannot be used as a major substrate for the energy metabolism of this tumour. Systemic ketosis (1-2 mM acetoacetate plus 3-hydroxybutyrate) was induced both in tumour-bearing and in non-tumour-bearing rats with a diet containing 70% medium chain triglyceride. However, in rats bearing the Walker 256 tumour, this dietary ketosis did not reduce the tumour growth rate nor did it prevent the subsequent decrease in host body weight. Host body nitrogen losses were similarly unaffected. The ketosis induced in tumour bearing rats was shown to be abnormal since the blood glucose concentration of ketotic, tumour-bearing rats was significantly higher compared with that of ketotic non-tumour bearing rats (5.2 +/- 0.4 mM cf 3.4 +/- 0.6 mM, P>0.01). These results may partly explain why systemic ketosis failed to alter the growth and cachexia induced by the Walker 256 carcinosarcoma.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Preston, Prof Thomas and Plumb, Dr Jane
Authors: Fearon, K.C., Tisdale, M.J., Preston, T., Plumb, J.A., and Calman, K.C.
College/School:College of Medical Veterinary and Life Sciences
College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:British Journal of Cancer
ISSN:0007-0920
ISSN (Online):1532-1827
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