25-hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid

Knox, S. et al. (2012) 25-hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid. Atherosclerosis, 223(2), pp. 437-441. (doi:10.1016/j.atherosclerosis.2012.05.001) (PMID:22632919)

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Abstract

Objective: The association of the circulating serum vitamin D metabolite 25-hydroxyvitamin D (25OHD) with atherosclerotic burden is unclear, with previous studies reporting disparate results. <p/>Method: Psychological, social and biological determinants of ill health (pSoBid) is a study of participants aged 35–64 years from Glasgow who live at extremes of the socioeconomic spectrum. Vitamin D deficiency was defined as 25OHD < 25nmol/L, as per convention. Cross-sectional associations between circulating 25OHD concentrations and a range of socioeconomic, lifestyle, and biochemistry factors, as well as carotid intima media thickness (cIMT) and plaque presence were assessed in 625 participants. <p/>Results: Geometric mean levels of circulating 25OHD were higher among the least deprived (45.6 nmol/L, 1-SD range 24.4–85.5) versus most deprived (34.2 nmol/L, 1-SD range 16.9–69.2; p < 0.0001). In the least deprived group 15% were “deficient” in circulating 25OHD versus 30.8% in the most deprived (χ2p < 0.0001). Log 25OHD was 27% lower among smokers (p < 0.0001), 20% higher among the physically active versus inactive (p = 0.01), 2% lower per 1 kg/m2 increase in body mass index (BMI) (p < 0.0001), and showed expected seasonal variation (χ2p < 0.0001). Log 25OHD was 13% lower in the most versus least deprived independent of the aforementioned lifestyle confounding factors (p = 0.03). One unit increase in log 25OHD was not associated with atherosclerotic burden in univariable models; cIMT (effect estimate 0.000 mm [95% CI −0.011, 0.012]); plaque presence (OR 0.88 [0.75, 1.03]), or in multivariable models. <p/>Conclusion: There is no strong association of 25OHD with cIMT or plaque presence, despite strong evidence 25OHD associates with lifestyle factors and socioeconomic deprivation.

Item Type:Articles
Additional Information:NOTICE: this is the author’s version of a work that was accepted for publication in Atherosclerosis 223(2)437-441. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Atherosclerosis 2012. DOI: 10.1016/j.atherosclerosis.2012.05.001
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Bezlyak, Dr Vladimir and McConnachie, Dr Alex and Batty, Mr David and Welsh, Dr Paul and Ford, Professor Ian and Tannahill, Dr Carol and Shiels, Professor Paul and Millar, Professor Keith and Cavanagh, Professor Jonathan and Velupillai, Dr Yoganathan and Boulton, Miss Emma and Packard, Professor Chris and Sattar, Professor Naveed
Authors: Knox, S., Welsh, P., Bezlyak, V., McConnachie, A., Boulton, E., Deans, K.A., Ford, I., Batty, G.D., Burns, H., Cavanagh, J., Millar, K., McInnes, I.B., Velupillai, Y., Shiels, P., Tannahill, C., Packard, C.J., Wallace, A.M., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:Atherosclerosis
Publisher:Elsevier Ireland Ltd
ISSN:0021-9150
Published Online:09 May 2012
Copyright Holders:Copyright © 2012 Elsevier
First Published:First published in Atherosclerosis
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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