Klymenko, T. and Graham, S. (2012) Human papillomavirus gene expression is controlled by host cell splicing factors. Biochemical Society Transactions, 40, pp. 773-777. (doi: 10.1042/BST20120079) (PMID:22817732)
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Abstract
Human papillomaviruses (HPV) infect stratified epithelia and cause a variety of lesions ranging from benign warts to invasive tumours. The virus life cycle is tightly linked to differentiation of the keratinocyte it infects: papillomaviruses modulate host gene expression to ensure efficient virus replication. For example, the viral transcription factor E2 can directly upregulate, in an epithelial differentiation-dependent manner, cellular SR (serine/arginine-rich) splicing factors that control constitutive and alternative splicing. Changes in alternative splicing and the mechanisms controlling this for viral mRNAs have been a subject to intense exploration. However, to date experiments have only been carried out in model systems because the genetic systems suitable for studying alternative splicing of viral RNAs in the context of the virus life cycle are relatively recent and technically challenging. Now using these life cycle-supporting systems, our laboratory has identified SR proteins as important players in differentiation-dependent regulation of HPV gene expression. Better understanding of the role of cellular factors in regulating the virus life cycle is needed as it may help development of novel diagnostic approaches and antiviral therapies in the future.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Graham, Professor Sheila and Klymenko, Dr Tetyana |
Authors: | Klymenko, T., and Graham, S. |
Subjects: | Q Science > QR Microbiology > QR355 Virology |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Biochemical Society Transactions |
Journal Abbr.: | Biochem. Soc. Trans. |
Publisher: | Portland Press |
ISSN: | 0300-5127 |
ISSN (Online): | 1470-8752 |
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