Robust signaling networks of the adipose secretome

Breitling, R. (2009) Robust signaling networks of the adipose secretome. Trends in Endocrinology and Metabolism, 20(1), pp. 1-7. (doi: 10.1016/j.tem.2008.08.006)

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Type 2 diabetes is a prototypical complex systems disease that has a strong hereditary component and etiologic links with a sedentary lifestyle, overeating and obesity. Adipose tissue has been shown to be a central driver of type 2 diabetes progression, establishing and maintaining a chronic state of low-level inflammation. The number and diversity of identified endocrine factors from adipose tissue (adipokines) is growing rapidly. Here, I argue that a systems biology approach to understanding the robust multi-level signaling networks established by the adipose secretome will be crucial for developing efficient type 2 diabetes treatment. Recent advances in whole-genome association studies, global molecular profiling and quantitative modeling are currently fueling the emergence of this novel research strategy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Breitling, Professor Rainer
Authors: Breitling, R.
Subjects:Q Science > QH Natural history > QH301 Biology
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Trends in Endocrinology and Metabolism
Published Online:17 October 2008

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