Breitling, R. (2009) Robust signaling networks of the adipose secretome. Trends in Endocrinology and Metabolism, 20(1), pp. 1-7. (doi: 10.1016/j.tem.2008.08.006)
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Publisher's URL: http://dx.doi.org/10.1016/j.tem.2008.08.006
Abstract
Type 2 diabetes is a prototypical complex systems disease that has a strong hereditary component and etiologic links with a sedentary lifestyle, overeating and obesity. Adipose tissue has been shown to be a central driver of type 2 diabetes progression, establishing and maintaining a chronic state of low-level inflammation. The number and diversity of identified endocrine factors from adipose tissue (adipokines) is growing rapidly. Here, I argue that a systems biology approach to understanding the robust multi-level signaling networks established by the adipose secretome will be crucial for developing efficient type 2 diabetes treatment. Recent advances in whole-genome association studies, global molecular profiling and quantitative modeling are currently fueling the emergence of this novel research strategy.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Breitling, Professor Rainer |
| Authors: | Breitling, R. |
| Subjects: | Q Science > QH Natural history > QH301 Biology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Trends in Endocrinology and Metabolism |
| ISSN: | 1043-2760 |
| Published Online: | 17 October 2008 |
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