Woodward, M., Lowe, G., Rumley, A., Imhof, A. and Koenig, W. (2003) Measurement of plasma viscosity in stored frozen samples: a general population study. Blood Coagulation and Fibrinolysis, 14(4), pp. 417-420.
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Publisher's URL: http://www.bloodcoagulation.com/pt/re/bcf/issuelist.htm
Abstract
To establish whether plasma viscosity could be accurately measured from frozen-stored (instead of fresh) plasma samples in epidemiological studies, we prospectively compared fresh and frozen-stored samples from 1361 men and women aged 25-74 years participating in the Glasgow MONICA survey. Mean plasma viscosity (37degreesC) was significantly higher (P lt 0.0001) in fresh samples (mean = 1.310 mPa/s, standard deviation = 0.079 mPa/s) compared with frozen samples (mean = 1.278 mPa/s, standard deviation = 0.075 mPa/s). However, this difference (mean = 0.030 mPa/s, 95% confidence interval = 0.029-0.031) did not vary significantly with increasing viscosity (kappa statistic for consistency of categorization by thirds = 0.824, standard error = 0.021). We conclude that frozen samples are acceptable for epidemiological studies of plasma viscosity, which should increase their utilization.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Rumley, Dr Ann and Lowe, Professor Gordon |
| Authors: | Woodward, M., Lowe, G., Rumley, A., Imhof, A., and Koenig, W. |
| Subjects: | R Medicine > RC Internal medicine |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Blood Coagulation and Fibrinolysis |
| ISSN: | 0957-5235 |
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