Urinary androgens and cortisol metabolites in field-sampled bonobos (Pan paniscus)

Dittami, J., Katina, S., Möstl, E., Eriksson, J., Machatschke, I.H. and Hohmann, G. (2008) Urinary androgens and cortisol metabolites in field-sampled bonobos (Pan paniscus). General and Comparative Endocrinology, 155(3), pp. 552-557. (doi: 10.1016/j.ygcen.2007.08.009)

Full text not currently available from Enlighten.


Urinarymetabolites of androgens and cortisol were measured in free-living male and female bonobos. Sex differences and correlations between adrenal and gonadal steroid excretion were investigated. The immunoreactive concentrations of androgens were measured with two different androgen assays. One assay used a testosterone (T) antibody raised with a 17β-hydroxy group, and the other employed an antibody raised against a reduced form, 5α-androstane-17α-ol-3-one-CM (17α) with cross reactivity for epitestosterone and 5α-androstanedione. Both assays have been used in bonobo and chimpanzee studies where non-invasive techniques were employed. The levels of 17α-androgenmetabolites were 1.7- and 3-fold higher than those of T-metabolites in males and females. The two androgen assay results correlated in males but not females. There was a sex difference in the T-metabolites measured. Male levels were significantly higher. Levels of 17α in the two sexes were similar. Cortisolmetabolite levels (CORT) were similar between the sexes. The T-metabolites were significantly correlated with CORT in males but not in females. In females, the 17α-androgenmetabolites correlated with CORT. This suggests that either androgen secretion or metabolism differs between the sexes. A parsimonious interpretation of the androgen assay cortisol/androgen correlation differences would be that larger components of dehydroepiandrosterone (DHEA), androstenedione or epitestosterone from the adrenal androgens were being excreted and measured in the females. The CORT/T metabolite interactions in males may reflect male-specific social or metabolic endocrine conditions.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Katina, Dr Stanislav
Authors: Dittami, J., Katina, S., Möstl, E., Eriksson, J., Machatschke, I.H., and Hohmann, G.
Subjects:Q Science > QA Mathematics
R Medicine > R Medicine (General)
College/School:College of Science and Engineering > School of Mathematics and Statistics > Statistics
Research Group:Statistical Modelling
Journal Name:General and Comparative Endocrinology
Publisher:Elsevier BV
Published Online:27 August 2007

University Staff: Request a correction | Enlighten Editors: Update this record