Tran, A.T., Cergol, K.M., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J. and Payne, R.J. (2010) Rapid assembly of potent type II dehydroquinase inhibitors via "Click" chemistry. MedChemComm, 1(4), pp. 271-275. (doi: 10.1039/c0md00097c)
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Abstract
The rapid synthesis of a library of potent type II dehydroquinase inhibitors is described. Inhibitors were prepared via a key quinate-derived ene-yne intermediate using Cu(1)-catalysed azide-alkyne cycloaddition (CuAAC) chemistry with a variety of aryl- and heteroaryl-azides.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lapthorn, Dr Adrian |
Authors: | Tran, A.T., Cergol, K.M., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J., and Payne, R.J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | MedChemComm |
ISSN: | 2040-2503 |
Published Online: | 23 August 2010 |
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