Approaches for developing novel microtubule targeting agents (MTas) for therapeutic exploitation

Krishnan, A., Wilson, J. and Leung, H.Y. (2012) Approaches for developing novel microtubule targeting agents (MTas) for therapeutic exploitation. Current Pharmaceutical Design, 18(19), pp. 2804-2810.

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Abstract

The microtubule (MT) represents a highly validated target for therapy. Insights into the complex nature of the dynamic microtubule physiology will provide the basis for developing novel microtubule targeting agents with enhanced efficacy and minimized toxicity. In this article, with an emphasis on translational applications, we have summarized relevant aspects of tubulin physiology in the context of developing MT binding agents as therapeutic agents. Case studies were included to illustrate therapeutic developments in prostate cancer and current strategies to discover novel agents or targets for therapy.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Leung, Professor Hing
Authors: Krishnan, A., Wilson, J., and Leung, H.Y.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Current Pharmaceutical Design
ISSN:1381-6128
ISSN (Online):1873-4286
Published Online:28 February 2012

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