Reducing the hypomania checklist (HCL-32) to a 16-item version

Forty, L. et al. (2010) Reducing the hypomania checklist (HCL-32) to a 16-item version. Journal of Affective Disorders, 124(3), pp. 351-356. (doi:10.1016/j.jad.2010.01.004)

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Background The under-recognition of hypomanic symptoms by both clinicians and patients is a major clinical problem which contributes to misdiagnosis and diagnostic delay in patients with bipolar disorder. The recent development of validated screening instruments for hypomania, such as the Hypomania Checklist (HCL-32), may help to improve the detection of bipolar disorder. In this study, we assess whether it is possible to reduce the number of items on the HCL-32 without any loss in the screening tool's ability to reliably differentiate between bipolar disorder (BD) and major depressive disorder (MDD).

Methods Using our large samples of patients with DSM-IV defined bipolar I disorder (BD-I) (n = 230) and recurrent MDD (n = 322), we performed item correlations in order to identify potentially redundant items in the HCL-32. We then tested the performance of a shortened 16-item HCL questionnaire within a separate sample of patients with BD (including BD-I, BD-II and BD-NOS) (n = 59) and MDD (n = 76).

Results The structure of the 16-item HCL demonstrated two main factors similar to those identified for the HCL-32 (an ‘active-elated’ factor and a ‘risk-taking/irritable’ factor). A score of 8 or more on a shortened 16-item version of the HCL had excellent ability to distinguish between BD and MDD. The sensitivity (83%) and specificity (71%) of the 16-item version were very similar to those for the full 32-item HCL.

Limitations The HCL-16 was derived after subjects had completed the full HCL-32. It will be important to test the validity of a ‘stand-alone’ 16-item HCL questionnaire.

Conclusions A shortened 16-item HCL (the HCL-16) is potentially a useful screening tool for hypomania within busy clinical settings.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Smith, Professor Daniel
Authors: Forty, L., Kelly, M., Jones, L., Jones, I., Barnes, E., Caesar, S., Fraser, C., Gordon-Smith, K., Griffiths, E., Craddock, N., and Smith, D.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:Journal of Affective Disorders
ISSN (Online):1573-2517
Published Online:02 February 2010

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