Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

Mulligan, A.M. et al. (2011) Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2. Breast Cancer Research, 13(6), R110. (doi:10.1186/bcr3052)

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Abstract

The associations of the 12 SNPs with risk for BRCA1 and BRCA2 carriers differ by ER-positive or ER-negative breast cancer status. The apparent differences in SNP associations between BRCA1 and BRCA2 carriers, and non-carriers, may be explicable by differences in the prevalence of tumour subtypes. As more risk modifying variants are identified, incorporating these associations into breast cancer subtype-specific risk models may improve clinical management for mutation carriers.

Item Type:Articles
Additional Information:Edward Tobias as a member of EMBRACE
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tobias, Professor Edward
Authors: Mulligan, A.M., Couch, F.J., Barrowdale, D., Domchek, S.M., Eccles, D., Nevanlinna, H., Ramus, S.J., Robson, M., Sherman, M., Spurdle, A.B., Wappenschmidt, B., Lee, A., McGuffog, L., Healey, S., Sinilnikova, O.M., Janavicius, R., Hansen, T.v.O., Nielsen, F.C., Ejlertsen, B., Osorio, A., Muñoz-Repeto, I., Durán, M., Godino, J., Pertesi, M., Benítez, J., Peterlongo, P., Manoukian, S., Peissel, B., Zaffaroni, D., Cattaneo, E., Bonanni, B., Viel, A., Pasini, B., Papi, L., Ottini, L., Savarese, A., Bernard, L., Radice, P., Hamann, U., Verheus, M., Meijers-Heijboer, H.E.J., Wijnen, J., Gómez García, E.B., Nelen, M.R., Kets, C.M., Seynaeve, C., Tilanus-Linthorst, M.M.A., van der Luijt, R.B., van Os, T., Rookus, M., Frost, D., Jones, J.L., Evans, D.G., Lalloo, F., Eeles, R., Izatt, L., Adlard, J., Davidson, R., Cook, J., Donaldson, A., Dorkins, H., Gregory, H., Eason, J., Houghton, C., Barwell, J., Side, L.E., McCann, E., Murray, A., Peock, S., Godwin, A.K., Schmutzler, R.K., Rhiem, K., Engel, C., Meindl, A., Ruehl, I., Arnold, N., Niederacher, D., Sutter, C., Deissler, H., Gadzicki, D., Kast, K., Preisler-Adams, S., Varon-Mateeva, R., Schoenbuchner, I., Fiebig, B., Heinritz, W., Schäfer, D., Gevensleben, H., Caux-Moncoutier, V., Fassy-Colcombet, M., Cornelis, F., Mazoyer, S., Léoné, M., Boutry-Kryza, N., Hardouin, A., Berthet, P., Muller, D., Fricker, J.-P., Mortemousque, I., Pujol, P., Coupier, I., Lebrun, M., Kientz, C., Longy, M., Sevenet, N., Stoppa-Lyonnet, D., Isaacs, C., Caldes, T., de la Hoya, M., Heikkinen, T., Aittomäki, K., Blanco, I., Lazaro, C., Barkardottir, R.B., Soucy, P., Dumont, M., Simard, J., Montagna, M., Tognazzo, S., D'Andrea, E., Fox, S., Yan, M., Rebbeck, T., Olopade, O., Weitzel, J.N., Lynch, H.T., Ganz, P.A., Tomlinson, G.E., Wang, X., Fredericksen, Z., Pankratz, V.S., Lindor, N.M., Szabo, C., Offit, K., Sakr, R., Gaudet, M., Bhatia, J., Kauff, N., Singer, C.F., Tea, M.-K., Gschwantler-Kaulich, D., Fink-Retter, A., Mai, P.L., Greene, M.H., Imyanitov, E., O'Malley, F.P., Ozcelik, H., Glendon, G., Toland, A.E., Gerdes, A.-M., Thomassen, M., Kruse, T.A., Jensen, U.B., Skytte, A.-B., Caligo, M.A., Soller, M., Henriksson, K., Wachenfeldt, v.A., Arver, B., Stenmark-Askmalm, M., Karlsson, P., Ding, Y.C., Neuhausen, S.L., Beattie, M., Pharoah, P.D.P., Moysich, K.B., Nathanson, K.L., Karlan, B.Y., Gross, J., John, E.M., Daly, M.B., Buys, S.M., Southey, M.C., Hopper, J.L., Terry, M.B., Chung, W., Miron, A.F., Goldgar, D., Chenevix-Trench, G., Easton, D.F., Andrulis, I.L., Antoniou, A.C., and Tobias, E.S.
Subjects:Q Science > QH Natural history > QH426 Genetics
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Breast Cancer Research
ISSN:1465-542X
Published Online:02 November 2011

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