Actin-bundling proteins in cancer progression at a glance

Stevenson, R.P., Veltman, D. and Machesky, L.M. (2012) Actin-bundling proteins in cancer progression at a glance. Journal of Cell Science, 125(5), pp. 1073-1079. (doi:10.1242/​jcs.093799)

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Abstract

Cells use their cytoskeletons to move, polarise, divide and maintain organisation within multicellular tissues. Actin is a highly conserved essential building block of the cytoskeleton that forms cables and struts, which are constantly remodelled by more than 100 different actin-binding proteins. The initiation of new actin filaments and their subsequent organisation is a key step in the development of specialised cellular structures, such as filopodia (spike-like protrusions), lamellipodia (sheet-like protrusions), stress fibers (elastic contractile bundles), microvilli (finger-like surface protrusions) and invadopodia (invasive cell feet) (see Table 1 for a more complete list). Whereas the cytoskeleton is important in normal cellular function, it can be subverted in cancer cells and contributes to changes in cell growth, stiffness, movement and invasiveness. We hereby give an overview of the role of actin-filament bundling in cellular structures and discuss how alterations in the activity or expression patterns of actin-bundling proteins could be linked to cancer initiation or progression.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Machesky, Professor Laura
Authors: Stevenson, R.P., Veltman, D., and Machesky, L.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Cell Science
ISSN:0021-9533

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