Ozçaka, O., Oztürk Ceyhan, B., Akcali, A., Biçakci, N., Lappin, D.F. and Budunelı, N. (2012) Is there an interaction between polycystic ovary syndrome and gingival inflammation? Journal of Periodontology, 83(12), pp. 1529-1537. (doi: 10.1902/jop.2012.110588)
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Abstract
<p>Aim: The aim of this study was to evaluate the gingival crevicular fluid (GCF), saliva and serum concentrations of tumour necrosis factor-alpha (TNF-α), TNF-α receptor-1, TNF-α receptor-2 and interleukin-6 (IL-6) in non-obese women with polycystic ovary syndrome (PCOS) and either clinically healthy periodontium or gingivitis.</p> <p>Materials & Methods: Thirty-one women with PCOS and healthy periodontium, 30 women with PCOS and gingivitis and 12 systemically and periodontally healthy women were included in the study. GCF, saliva, and serum samples were collected and clinical periodontal measurements, body mass index (BMI) and Ferriman-Gallwey score (FGS) were recorded. Sex hormones, cortisol and insulin levels were measured. TNF-α, TNF-α receptor-1, TNF-α receptor-2 and IL-6 were determined by enzyme-linked immunosorbent assay (ELISA). Kruskal-Wallis followed by Bonferroni corrected post hoc Mann-Whitney U tests were used to analyse the data.</p> <p>Results: PCOS+gingivitis group revealed significantly higher GCF, saliva, and serum IL-6 concentrations than PCOS+healthy group (p<0.0001). The two PCOS groups exhibited significantly higher saliva TNF-α concentrations than the control group (p=0.014 and p=0.023, respectively). FGS index was significantly higher in PCOS+gingivitis group than PCOS+healthy group (p=0.030). PCOS+gingivitis group revealed significantly higher insulin concentration than PCOS+healthy and control groups (p=0.014 and p<0.0001, respectively). Serum TNF-α, TNF-αRs and serum, GCF and salivary IL-6 levels correlated with the clinical periodontal measurements.</p> <p>Conclusion: PCOS and gingival inflammation appear to act synergistically on the pro-inflammatory cytokines; IL-6 and TNF-α. Thus, PCOS may have an impact on gingival inflammation or vice versa. Further studies are warranted to clarify the possible relationship between PCOS and periodontal disease.</p>
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lappin, Dr David |
| Authors: | Ozçaka, O., Oztürk Ceyhan, B., Akcali, A., Biçakci, N., Lappin, D.F., and Budunelı, N. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School |
| Journal Name: | Journal of Periodontology |
| ISSN: | 0022-3492 |
| ISSN (Online): | 1943-3670 |
| Published Online: | 17 April 2012 |
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