Randomized trial of two foam dressings in the management of chronic venous ulceration

Franks, P.J., Moody, M., Moffatt, C.J., Hiskett, G., Gatto, P., Davies, C., Furlong, W.T., Barrow, E. and Thomas, H. (2007) Randomized trial of two foam dressings in the management of chronic venous ulceration. Wound Repair and Regeneration, 15(2), pp. 197-202. (doi: 10.1111/j.1524-475X.2007.00205.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1524-475X.2007.00205.x

Abstract

A multicenter prospective randomized clinical trial was undertaken to compare two foam dressings (Allevyn Hydrocellular, Smith and Nephew and Mepilex, Molnlycke Health Care AB) in the management of chronic venous leg ulceration. Patients were also randomized to two compression bandage systems (4-layer vs. cohesive short stretch) as a factorial design. Those with causes of ulceration other than venous disease were excluded. In all, 156 patients met the entry criteria and were randomized from the 12 clinical centers with a median (range) ulcer size of 4.33 (0.33-123.10) cm(2). After 24 weeks a total of 100 (64.1%) patients had complete ulcer closure, 46 (29.5%) had withdrawn from the trial, nine (5.8%) remained unhealed and one patient died. Of the patients randomized to Mepilex, 50/75 (66.7%) had complete ulcer healing compared with 50/81 (61.7%) on Allevyn. The hazard ratio for healing after adjustment for bandage type and trial center was 1.48 (95% C.I. 0.87-2.54, p=0.15), which only marginally changed following adjustment for baseline variables, neither of which achieved statistical significance (p=0.16). Withdrawal rates were similar between groups (23, 30.7% Mepilex vs. 23, 28.4% Allevyn). Pain improved following treatment with both dressings (p<0.001), but with no difference between dressings.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Franks, Professor Peter
Authors: Franks, P.J., Moody, M., Moffatt, C.J., Hiskett, G., Gatto, P., Davies, C., Furlong, W.T., Barrow, E., and Thomas, H.
Subjects:R Medicine > RD Surgery
R Medicine > RL Dermatology
R Medicine > RT Nursing
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Nursing and Health Care
Journal Name:Wound Repair and Regeneration
ISSN:1067-1927
ISSN (Online):1524-475X
Published Online:09 March 2007

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