Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster

Baker, D. A., Meadows, L. A., Wang, J., Dow, J. A.T. and Russell, S. (2007) Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster. BMC Genomics, 8, p. 454. (doi:10.1186/1471-2164-8-454)

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Abstract

Background: Wild-type laboratory strains of model organisms are typically kept in isolation for many years, with the action of genetic drift and selection on mutational variation causing lineages to diverge with time. Natural populations from which such strains are established, show that gender-specific interactions in particular drive many aspects of sequence level and transcriptional level variation. Here, our goal was to identify genes that display transcriptional variation between laboratory strains of Drosophila melanogaster, and to explore evidence of gender-biased interactions underlying that variability. Results: Transcriptional variation among the laboratory genotypes studied occurs more frequently in males than in females. Qualitative differences are also apparent to suggest that genes within particular functional classes disproportionately display variation in gene expression. Our analysis indicates that genes with reproductive functions are most often divergent between genotypes in both sexes, however a large proportion of female variation can also be attributed to genes without expression in the ovaries. Conclusion: The present study clearly shows that transcriptional variation between common laboratory strains of Drosophila can differ dramatically due to sexual dimorphism. Much of this variation reflects sex-specific challenges associated with divergent physiological trade-offs, morphology and regulatory pathways operating within males and females.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wang, Mrs Jing and Dow, Professor Julian
Authors: Baker, D. A., Meadows, L. A., Wang, J., Dow, J. A.T., and Russell, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:BMC Genomics
Publisher:Biomed Central
ISSN:1471-2164
ISSN (Online):1471-2164
First Published:First published online in BMC Genomics 8:454
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
325421Affymetrix array service for the UK Drosophila CommunityJulian DowBiotechnology and Biological Sciences Research Council (BBSRC)G17767Institute of Molecular Cell and Systems Biology