The developmental, molecular, and transport biology of Malpighian tubules

Beyenbach, K.W., Skaer, H. and Dow, J.A.T. (2010) The developmental, molecular, and transport biology of Malpighian tubules. Annual Review of Entomology, 55, pp. 351-374. (doi: 10.1146/annurev-ento-112408-085512) (PMID:19961332)

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Molecular biology is reaching new depths in our understanding of the development and physiology of Malpighian tubules. In Diptera, Malpighian tubules derive from ectodermal cells that evaginate from the primitive hindgut and subsequently undergo a sequence of orderly events that culminates in an active excretory organ by the time the larva takes its first meal. Thereafter, the tubules enlarge by cell growth. Just as modern experimental strategies have illuminated the development of tubules, genomic, transcriptomic, and proteomic studies have uncovered new tubule functions that serve immune defenses and the breakdown and renal clearance of toxic substances. Moreover, genes associated with specific diseases in humans are also found in flies, some of which, astonishingly, express similar pathophenotypes. However, classical experimental approaches continue to show their worth by distinguishing between -omic possibilities and physiological reality while providing further detail about the rapid regulation of the transport pathway through septate junctions and the reversible assembly of proton pumps.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Dow, Professor Julian
Authors: Beyenbach, K.W., Skaer, H., and Dow, J.A.T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Annual Review of Entomology
ISSN (Online):1545-4487

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
433611Genetic, proteomic and functional analysis of junctional complexes in DrosophilaJulian DowBiotechnology and Biological Sciences Research Council (BBSRC)BB/F021240/1Institute of Molecular Cell and Systems Biology