Practical experience of ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland

Laws, P.M. et al. (2011) Practical experience of ustekinumab in the treatment of psoriasis: experience from a multicentre, retrospective case cohort study across the U.K. and Ireland. British Journal of Dermatology, 166(1), pp. 189-195. (doi: 10.1111/j.1365-2133.2011.10638.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1365-2133.2011.10638.x

Abstract

<b>Background</b>  There are limited data on the use of ustekinumab outside of clinical trials.<p></p> <b>Objectives</b>  To assess the efficacy and safety of ustekinumab in patients with severe psoriasis attending 10 dermatology centres in the U.K. and Ireland.<p></p> <b>Methods</b>  A retrospective case-note review of 129 patients with psoriasis treated with ustekinumab.<p></p> <b>Results</b>  Baseline Psoriasis Area and Severity Index (PASI) was 22·9 ± 10·1 (mean ± SD). After 16 weeks of treatment with ustekinumab PASI 75 (75% reduction in PASI) was observed in 63·0% (n = 80/127) of patients, although four patients required concomitant therapy at the 16-week time point. Previous biologic use did show a small, non-significant trend towards treatment failure. A PASI 75 response was seen in 29·4% (n = 5/17) of individuals weighing 90–100 kg and treated with the standard 45 mg ustekinumab dose compared with PASI 75 of 70·3%, 71·4%, 75·0% and 55·6% for weight groups < 80, 80–90, 100–110 and > 110 kg, respectively (P = 0·024). Ustekinumab therapy was well tolerated; serious adverse events were observed in 2·3% (n = 3/129) of patients.<p></p> <b>Conclusions</b>  Ustekinumab is a novel biologic agent for psoriasis. When used in everyday clinical practice it demonstrates high levels of short-term therapeutic efficacy with an acceptable short-term safety profile.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Burden, Professor David
Authors: Laws, P.M., Downs, A.M., Parslew, R., Dever, B., Smith, C.H., Barker, J.N., Moriarty, B., Murphy, R., Kirby, B., Burden, A.D., McBride, S., Anstey, A.V., O’Shea, S., Ralph, N., Buckley, C., Griffiths, C.E.M., and Warren, R.B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:British Journal of Dermatology
ISSN:0007-0963
ISSN (Online):1365-2133
Published Online:27 December 2011

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