Kerr, D.M., Fulton, R.L., Higgins, P., Bath, P.M.W., Shuaib, A., Lyden, P. and Lees, K.R. (2012) Response of blood pressure and blood glucose to treatment with recombinant tissue-type plasminogen activator in acute ischemic stroke: evidence from the virtual international stroke trials archive. Stroke, 43(2), pp. 399-404. (doi: 10.1161/STROKEAHA.111.627059)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1161/STROKEAHA.111.627059
Abstract
<b>BACKGROUND AND PURPOSE:</b> Elevations in blood pressure (BP) and blood glucose are common during stroke and may represent a stress response secondary to the acute neurological deficit. If so, they should settle more completely in recombinant tissue-type plasminogen activator (rtPA)-treated patients in association with improved neurological status.<p></p> <b>METHODS:</b> We performed a controlled comparison of 24-hour declines in BP and glucose in rtPA-treated and control patients from the Virtual Stroke International Stroke Trial Archive (VISTA) database. Twenty-four-hour falls in BP and glucose were compared using multiple regression to account for baseline imbalances. The logarithmic transformation of glucose was used and 24-hour differences expressed as ratios of 24 hours to admission geometric means. Two-way analysis of variance was used to test for interaction between rtPA and early improvement for 24-hour falls in BP and blood glucose.<p></p> <b>RESULTS:</b> BP analysis included 5406 patients (rtPA=41%) and glucose analysis 4288 (rtPA=37%). rtPA-treated patients were younger, less likely to have a history of hypertension or diabetes, and had more severe strokes on admission. BP and glucose were lower at baseline in rtPA-treated patients than control subjects. On regression, rtPA predicted significantly greater 24-hour falls in systolic BP (β=3.9; 95% CI, 2.8-5.0), diastolic BP (β=3.1; 95% CI, 2.4-3.9), and glucose (β=0.97; 95% CI, 0.95-0.99). rtPA did not interact with early neurological improvement for 24-hour falls in systolic BP (P=0.72), diastolic BP (P=0.79), or blood glucose (P=0.51).<p></p> <b>CONCLUSIONS:</b> A stress response does not appear to be the principal cause of elevations in BP and glucose during stroke.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Macisaac, Dr Rachael and Kerr, Dr Daniel and Lees, Professor Kennedy and Higgins, Dr Peter |
Authors: | Kerr, D.M., Fulton, R.L., Higgins, P., Bath, P.M.W., Shuaib, A., Lyden, P., and Lees, K.R. |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Stroke |
ISSN: | 0039-2499 |
ISSN (Online): | 1524-4628 |
Published Online: | 10 November 2011 |
University Staff: Request a correction | Enlighten Editors: Update this record