Periodontitis, porphyromonas, and the pathogenesis of rheumatoid arthritis

Farquharson, D., Butcher, J.P. and Culshaw, S. (2012) Periodontitis, porphyromonas, and the pathogenesis of rheumatoid arthritis. Mucosal Immunology, 5(2), pp. 112-120. (doi:10.1038/mi.2011.66)

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Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiologies and pathogenesis themselves remain incompletely understood. Could there really be an etiological link or does this simply represent a statistical coincidence muddied by common risk factors? This review seeks to provide background on these two diseases in the context of recent discoveries suggesting that their pathogenesis may be related. In particular, the process of citrullination, a post-translational protein modification, has been highlighted as a process common to both diseases. The evidence for a relationship between the diseases is explored and its potential mechanisms discussed.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Butcher, Mr John and Culshaw, Professor Shauna
Authors: Farquharson, D., Butcher, J.P., and Culshaw, S.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Mucosal Immunology
ISSN (Online):1935-3456
Published Online:25 January 2012

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