Fetuin A concentration in the second trimester amniotic fluid of fetuses with Trisomy 21 appears to be lower: phenotypic considerations

Iliodromiti, S., Vrachnis, N., Samoli, E., Iliodromiti, Z., Pangalos, C., Drakoulis, N., Creatsas, G. and Botsis, D. (2012) Fetuin A concentration in the second trimester amniotic fluid of fetuses with Trisomy 21 appears to be lower: phenotypic considerations. Mediators of Inflammation, 2012, pp. 1-4. (doi: 10.1155/2012/138971)

Abstract

Objective: We investigated whether the concentration of the glycoprotein fetuin A is altered in the second trimester amniotic fluid of trisomy 21 pregnancies compared with euploid pregnancies. Methods. 25 pregnancies with an extra chromosome 21 were matched for maternal and gestational age with 25 pregnancies with normal karyotype. Levels of fetuin A in amniotic fluid were measured by a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Results: The median concentration of fetuin A in amniotic fluid of trisomy 21 pregnancies (5.3 ng/ml) was statistically significantly lower (P value = 0.008) compared with that in euploid pregnancies (6.8 ng/mL). Conclusion: Lower levels of fetuin A in trisomy 21 may indicate an association with altered metabolic pathways in this early stage that could potentially be associated with features of the syndrome, such as growth restriction or impaired osteogenesis

• Item Type: Articles
• Additional Information: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Iliodromiti, Dr Stamatina
• Authors: Iliodromiti, S., Vrachnis, N., Samoli, E., Iliodromiti, Z., Pangalos, C., Drakoulis, N., Creatsas, G., and Botsis, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Mediators of Inflammation
• Publisher: Hindawi Publishing Corporation
• ISSN: 0962-9351
• ISSN (Online): 1466-1861
• Copyright Holders: Copyright © 2012 S. Iliodromiti et al.
• First Published: First published in Mediators of Inflammation 2012 Article ID 138971 p. 1-4
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher