Analysis of malaria parasite phenotypes using experimental genetic crosses of Plasmodium falciparum

Ranford-Cartwright, L.C. and Mwangi, J.M. (2012) Analysis of malaria parasite phenotypes using experimental genetic crosses of Plasmodium falciparum. International Journal for Parasitology, 42(6), pp. 529-534. (doi:10.1016/j.ijpara.2012.03.004)

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Abstract

We review the principles of linkage analysis of experimental genetic crosses and their application to Plasmodium falciparum. Three experimental genetic crosses have been performed using the human malaria parasite P. falciparum. Linkage analysis of the progeny of these crosses has been used to identify parasite genes important in phenotypes such as drug resistance, parasite growth and virulence, and transmission to mosquitoes. The construction and analysis of genetic maps has been used to characterise recombination rates across the parasite genome and to identify hotspots of recombination.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ranford-Cartwright, Dr Lisa and Mwangi, Dr Jonathan
Authors: Ranford-Cartwright, L.C., and Mwangi, J.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:International Journal for Parasitology
ISSN:0020-7519

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
534421Genetic analysis of growth rates in Plasmodium falciparumLisa Ranford-CartwrightWellcome Trust (WELLCOME)091791/Z/10/ZIII - BACTERIOLOGY
395071Identification of Plasmodium falciparum QTL determining differential infectivity to Anopheles mosquitoesLisa Ranford-CartwrightWellcome Trust (WELLCOME)078749/Z/05/ZIII - BACTERIOLOGY