Cornet, I., Bouvard, V., Campo, M.S., Thomas, M., Banks, L., Gissmann, L., Lamartine, J., Sylla, B.S., Accardi, R. and Tommasino, M. (2012) Comparative analysis of transforming properties of E6 and E7 from different beta human papillomavirus types. Journal of Virology, 86(4), pp. 2366-2370. (doi: 10.1128/JVI.06579-11)
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Publisher's URL: http://dx.doi.org/10.1128/JVI.06579-11
Abstract
The cutaneous beta human papillomavirus (beta HPV) types appear to be involved in skin carcinogenesis. However, only a few beta HPVs have been investigated so far. Here, we compared the properties of E6 and E7 oncoproteins from six uncharacterized beta HPVs (14, 22, 23, 24, 36, 49). Only HPV49 E6 and E7 immortalized primary human keratinocytes and efficiently deregulated the p53 and pRb pathways. Furthermore, HPV49 E6, similarly to E6 from the oncogenic HPV16, promoted p53 degradation.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Campo, M Saveria |
| Authors: | Cornet, I., Bouvard, V., Campo, M.S., Thomas, M., Banks, L., Gissmann, L., Lamartine, J., Sylla, B.S., Accardi, R., and Tommasino, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Journal of Virology |
| Journal Abbr.: | J. Virol. |
| ISSN: | 0022-538X |
| ISSN (Online): | 1098-5514 |
| Published Online: | 14 December 2011 |
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