Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in Tsetse in Serengeti, Tanzania

Auty, H.K., Picozzi, K., Malele, I., Torr, S.J., Cleaveland, S. and Welburn, S. (2012) Using molecular data for epidemiological inference: assessing the prevalence of Trypanosoma brucei rhodesiense in Tsetse in Serengeti, Tanzania. PLoS Neglected Tropical Diseases, 6(1), e1501. (doi:10.1371/journal.pntd.0001501)

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Abstract

Measuring the prevalence of transmissible <i>Trypanosoma brucei rhodesiense</i> in tsetse populations is essential for understanding transmission dynamics, assessing human disease risk and monitoring spatio-temporal trends and the impact of control interventions. Although an important epidemiological variable, identifying flies which carry transmissible infections is difficult, with challenges including low prevalence, presence of other trypanosome species in the same fly, and concurrent detection of immature non-transmissible infections. Diagnostic tests to measure the prevalence of <i>T. b. rhodesiense</i> in tsetse are applied and interpreted inconsistently, and discrepancies between studies suggest this value is not consistently estimated even to within an order of magnitude.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cleaveland, Professor Sarah and Auty, Harriet
Authors: Auty, H.K., Picozzi, K., Malele, I., Torr, S.J., Cleaveland, S., and Welburn, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:PLoS Neglected Tropical Diseases
Publisher:Public Library of Science
ISSN:1935-2727
ISSN (Online):1935-2735
Published Online:31 January 2012
Copyright Holders:Copyright © 2012 The Authors
First Published:First published in PLoS Neglected Tropical Diseases 6(1):e1501
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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