Herd-level risk factors associated with the presence of Phage type 21/28 E. coli O157 on Scottish cattle farms

Halliday, J.E.B. , Chase-Topping, M.E., Pearce, M.C., McKendrick, I.J., Allison, L., Fenlon, D., Low, C., Mellor, D.J. , Gunn, G.J. and Woolhouse, M.E.J. (2006) Herd-level risk factors associated with the presence of Phage type 21/28 E. coli O157 on Scottish cattle farms. BMC Microbiology, 6(99), (doi:10.1186/1471-2180-6-99)

[img]
Preview
Text
60967.pdf
Available under License Creative Commons Attribution.

315kB

Abstract

<p>Background: E. coli O157 is a bacterial pathogen that is shed by cattle and can cause severe disease in humans. Phage type (PT) 21/28 is a subtype of E. coli O157 that is found across Scotland and is associated with particularly severe human morbidity.</p> <p>Methods: A cross-sectional survey of Scottish cattle farms was conducted in the period Feb 2002-Feb 2004 to determine the prevalence of E. coli O157 in cattle herds. Data from 88 farms on which E. coli O157 was present were analysed using generalised linear mixed models to identify risk factors for the presence of PT 21/28 specifically.</p> <p>Results: The analysis identified private water supply, and northerly farm location as risk factors for PT 21/28 presence. There was a significant association between the presence of PT 21/28 and an increased number of E. coli O157 positive pat samples from a farm, and PT 21/28 was significantly associated with larger E. coli O157 counts than non-PT 21/28 E. coli O157.</p> <p>Conclusion: PT 21/28 has significant risk factors that distinguish it from other phage types of E. coli O157. This finding has implications for the control of E. coli O157 as a whole and suggests that control could be tailored to target the locally dominant PT.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mellor, Professor Dominic and Halliday, Dr Joanna
Authors: Halliday, J.E.B., Chase-Topping, M.E., Pearce, M.C., McKendrick, I.J., Allison, L., Fenlon, D., Low, C., Mellor, D.J., Gunn, G.J., and Woolhouse, M.E.J.
Subjects:Q Science > Q Science (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:BMC Microbiology
ISSN:1471-2180
Published Online:02 December 2006
Copyright Holders:Copyright © 2006 The Authors
First Published:First published in BMC Microbiology 6(99)
Publisher Policy:Reproduced under a Creative Commons Licence

University Staff: Request a correction | Enlighten Editors: Update this record