Yuda, M., Iwanaga, S., Shigenobu, S., Mair, G.R., Janse, C.J., Waters, A.P. , Kato, T. and Kaneko, I. (2009) Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. Molecular Microbiology, 71(6), pp. 1402-1414. (doi: 10.1111/j.1365-2958.2009.06609.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1365-2958.2009.06609.x
Abstract
Gene expression in <i>Plasmodium</i> parasites undergoes significant changes in each developmental stage, but the transcription factors (TFs) regulating these changes have not been identified. We report here a <i>Plasmodium</i> TF (AP2-O) that activates gene expression in ookinetes, the mosquito-invasive form, and has a DNA-binding domain structurally related to that of a plant TF, Apetala2 (AP2). AP2-O mRNA is pre-synthesized by intraerythrocytic female gametocytes and translated later during ookinete development in the mosquito. The <i>Plasmodium</i> TF activates a set of genes, including all genes reported to be required for midgut invasion, by binding to specific six-base sequences on the proximal promoter. These results indicate that AP2 family TFs have important roles in stage-specific gene regulation in <i>Plasmodium</i> parasites.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Waters, Professor Andy |
Authors: | Yuda, M., Iwanaga, S., Shigenobu, S., Mair, G.R., Janse, C.J., Waters, A.P., Kato, T., and Kaneko, I. |
Subjects: | Q Science > QR Microbiology > QR355 Virology Q Science > QH Natural history > QH345 Biochemistry |
College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Molecular Microbiology |
ISSN: | 0950-382X |
ISSN (Online): | 1365-2958 |
Published Online: | 10 February 2009 |
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