New roles for endosomes: from vesicular carriers to multi-purpose platforms

Gould, G.W. and Lippincott-Schwartz, J. (2009) New roles for endosomes: from vesicular carriers to multi-purpose platforms. Nature Reviews Molecular Cell Biology, 10(4), pp. 287-292. (doi:10.1038/nrm2652)

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Publisher's URL: http://dx.doi.org/10.1038/nrm2652

Abstract

The careful sorting and recycling of membranes and cargo and the intracellular delivery of proteins, toxins and viruses by endocytosis are well-established roles for the endocytic apparatus, which is present in all eukaryotic cells. Recently, it has become clear that endosomes have key roles in such diverse processes as cytokinesis, polarization and migration, in which their functions might be distinct from those classically associated with endosomes. We speculate that endosomes function as multifunctional platforms on which unique sets of molecular machines are assembled to suit different cellular roles

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gould, Professor Gwyn
Authors: Gould, G.W., and Lippincott-Schwartz, J.
Subjects:Q Science > QH Natural history > QH345 Biochemistry
Q Science > QH Natural history > QH301 Biology
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Nature Reviews Molecular Cell Biology
ISSN:1471-0072

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