Caldwell, S.T. , McPhail, D.B., Duthie, G.D. and Hartley, R.C. (2012) Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants. Canadian Journal of Chemistry = Journal canadien de chimie, 90(1), pp. 23-33. (doi: 10.1139/V11-087)
Full text not currently available from Enlighten.
Abstract
Antioxidants have potential for the treatment of stroke and neurodegeneration, and chimeric compounds that combine a flavon-3-ol head group related to myricetin and a lipophilic decyl tail are known to protect membranes from oxidative damage at least as well as vitamin E. New flavon-3-ols that are highly hydroxylated in the B ring in ways not found in natural flavon-3-ols and bearing a lipophilic decyl tail have been prepared from trimethoxy- and tetramethoxybenzoic acids accessed by lithiation–carboxylation reactions. Direct enolate acylation was preferred over Baker–Venkataraman rearrangement when there were methoxy groups at both the 2- and the 6-position of the benzoic acid derivatives.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Caldwell, Dr Stuart and Hartley, Professor Richard |
| Authors: | Caldwell, S.T., McPhail, D.B., Duthie, G.D., and Hartley, R.C. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Canadian Journal of Chemistry = Journal canadien de chimie |
| ISSN: | 0008-4042 |
| Published Online: | 06 October 2011 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details