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Elevated circulating Interleukin-6 is associated with an acute-phase response but reduced fixed hepatic protein synthesis in patients with cancer

Fearon, K.C.H., McMillan, D.C., Preston, T., Winstanley, F.P., Cruickshank, A.M., and Shenkin, A. (1991) Elevated circulating Interleukin-6 is associated with an acute-phase response but reduced fixed hepatic protein synthesis in patients with cancer. Annals of Surgery, 213 (1). pp. 26-31. ISSN 0003-4932

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Abstract

It has been suggested that, as part of the inflammatory response to the presence of a tumor, various cytokines are produced and these induce hepatic synthesis of acute-phase proteins (APP). Under these circumstances it is not known what changes occur in the fixed component of hepatic protein synthesis. The aim of this study was to compare circulating interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF) concentrations and fixed hepatic protein synthesis rates in a group of healthy controls (n = 6) with a group of patients with an established APP response secondary to hepatic metastasis from colorectal cancer (n = 6). Fixed hepatic protein synthesis rates were measured following a primed, constant 20-hour infusion of 15N-glycine. The liver was biopsied at laparotomy. The APP response was assessed by serum C-reactive protein concentration and cytokines were assayed by a combination of immunoassay and bioassay. The patients with advanced cancer and an on-going APP response had elevated circulating IL-6 concentrations (p < 0.01). Rates of fixed hepatic protein synthesis were 30% lower than those observed in controls (p < 0.01). These findings demonstrate that in patients with hepatic metastasis, although the synthesis of certain acute-phase export proteins can be increased, fixed protein synthesis is reduced. Whether these changes in the distribution of hepatic protein synthesis are mediated by IL-6 will require further investigation.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Preston, Prof Thomas and McMillan, Prof Donald
Authors: Fearon, K.C.H., McMillan, D.C., Preston, T., Winstanley, F.P., Cruickshank, A.M., and Shenkin, A.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine
College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:Annals of Surgery
ISSN:0003-4932
ISSN (Online):1528-1140
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