McMillan, D.C., O'Gorman, P., Fearon, K.C.H., and McArdle, C.S. (1997) A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients. British Journal of Cancer, 76 (6). pp. 788-790. ISSN 0007-0920 (doi:10.1038/bjc.1997.463)
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Publisher's URL: http://dx.doi.org/10.1038/bjc.1997.463
Advanced gastrointestinal cancer patients with weight loss and an acute-phase response (n = 15) were given megestrol acetate (480 mg day(-1)) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an increase in body weight (P = 0.01) and a reduction in C-reactive protein concentrations (P = 0.02), with no change in total body water (P = 0.24) over this period. This regimen may be an effective non-toxic treatment for cancer cachexia and is worthy of further study.
|Glasgow Author(s):||McMillan, Prof Donald|
|Authors:||McMillan, D.C., O'Gorman, P., Fearon, K.C.H., and McArdle, C.S.|
|College/School:||College of Medical Veterinary and Life Sciences > School of Medicine|
|Journal Name:||British Journal of Cancer|
|Journal Abbr.:||Br. J. Cancer|