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A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients

McMillan, D.C., O'Gorman, P., Fearon, K.C.H., and McArdle, C.S. (1997) A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients. British Journal of Cancer, 76 (6). pp. 788-790. ISSN 0007-0920 (doi:10.1038/bjc.1997.463)

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Publisher's URL: http://dx.doi.org/10.1038/bjc.1997.463

Abstract

Advanced gastrointestinal cancer patients with weight loss and an acute-phase response (n = 15) were given megestrol acetate (480 mg day(-1)) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an increase in body weight (P = 0.01) and a reduction in C-reactive protein concentrations (P = 0.02), with no change in total body water (P = 0.24) over this period. This regimen may be an effective non-toxic treatment for cancer cachexia and is worthy of further study.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMillan, Prof Donald
Authors: McMillan, D.C., O'Gorman, P., Fearon, K.C.H., and McArdle, C.S.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine
Journal Name:British Journal of Cancer
Journal Abbr.:Br. J. Cancer
ISSN:0007-0920
ISSN (Online):1532-1827

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