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The relationship between weight loss and interleukin 6 in non-small-cell lung cancer

Scot, H.R., McMillan, D.C., Crilly, A., McArdl, C.S., and Milroy, R. (1996) The relationship between weight loss and interleukin 6 in non-small-cell lung cancer. British Journal of Cancer, 73 (12). pp. 1560-1562. ISSN 0007-0920 (doi:10.1038/bjc.1996.294)

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Publisher's URL: http://dx.doi.org/10.1038/bjc.1996.294

Abstract

Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and platelets (P < 0.01) in the weight-losing group. Moreover, there was a statistically significant correlation (r = 0.785, P < 0.001) between interleukin 6 and C-reactive protein concentrations. These results are consistent with interleukin 6 and the acute phase response promoting weight loss in NSCLC.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMillan, Prof Donald
Authors: Scot, H.R., McMillan, D.C., Crilly, A., McArdl, C.S., and Milroy, R.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine
Journal Name:British Journal of Cancer
Journal Abbr.:Br. J. Cancer
ISSN:0007-0920
ISSN (Online):1532-1827

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