Scot, H.R., McMillan, D.C., Crilly, A., McArdl, C.S., and Milroy, R. (1996) The relationship between weight loss and interleukin 6 in non-small-cell lung cancer. British Journal of Cancer, 73 (12). pp. 1560-1562. ISSN 0007-0920 (doi:10.1038/bjc.1996.294)
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Publisher's URL: http://dx.doi.org/10.1038/bjc.1996.294
Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and platelets (P < 0.01) in the weight-losing group. Moreover, there was a statistically significant correlation (r = 0.785, P < 0.001) between interleukin 6 and C-reactive protein concentrations. These results are consistent with interleukin 6 and the acute phase response promoting weight loss in NSCLC.
|Glasgow Author(s):||McMillan, Prof Donald|
|Authors:||Scot, H.R., McMillan, D.C., Crilly, A., McArdl, C.S., and Milroy, R.|
|College/School:||College of Medical Veterinary and Life Sciences > School of Medicine|
|Journal Name:||British Journal of Cancer|
|Journal Abbr.:||Br. J. Cancer|