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Respiratory control in infants at increased risk for sudden infant death syndrome

Parks, Y.A., Paton, J.Y., Beardsmore, C.S., MacFadyen, U.M., Thompson, J., Goodenough, P.C., and Simpson, H. (1989) Respiratory control in infants at increased risk for sudden infant death syndrome. Archives of Disease in Childhood, 64 (6). pp. 791-797. ISSN 0003-9888 (doi:10.1136/adc.64.6.791 )

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Abstract

There is much debate relating to possible abnormalities in respiratory control mechanisms in infants considered at increased risk for sudden infant death syndrome (SIDS). The P0.1 occlusion technique was used to assess the central respiratory response to hyperoxic hypercapnia during quiet sleep in 21 normal infants, 13 siblings of SIDS victims, and 17 infants with apparent life threatening events. The slope of P0.1 plotted against carbon dioxide concentration increased exponentially with age, independent of body weight in each group. Birth weight has a significant effect on slope with a lower weight predisposing to a lower slope. Siblings as a group had a significantly lower slope at any given age than normal infants, whereas the infants who had had apparent life threatening events were not significantly different from the controls. As intragroup variation in both siblings and control groups greatly exceeded the significant intergroup differences observed, the technique cannot identify individual infants as belonging to one or other group.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Paton, Dr James
Authors: Parks, Y.A., Paton, J.Y., Beardsmore, C.S., MacFadyen, U.M., Thompson, J., Goodenough, P.C., and Simpson, H.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities
Journal Name:Archives of Disease in Childhood
Journal Abbr.:Arch. Dis. Child.
ISSN:0003-9888
ISSN (Online):1468-2044

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