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The cholinergic regulation of potassium (86Rb ) permeability in sweat glands isolated from patients with cystic fibrosis

Wilson, S.M., Pediani, J., Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y., Coutts, J., Davidson, R., Lambert, J., and Morris, G. (1991) The cholinergic regulation of potassium (86Rb ) permeability in sweat glands isolated from patients with cystic fibrosis. Experimental Physiology, 76 (4). pp. 573-578. ISSN 0958-0670

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Publisher's URL: http://ep.physoc.org/content/76/4/573

Abstract

Sweat glands isolated from skin obtained from normal subjects and patients with cystic fibrosis (CF) were pre-loaded with 86Rb+ and superfused with a physiological salt solution and the rate of 86Rb+ efflux was measured as an indicator of cellular potassium permeability. Acetylcholine always evoked a permeability increase in the glands from control subjects and this response could be resolved into calcium-dependent and calcium-independent components. Sweat glands from CF patients did not show such consistent responses. In three individuals the glands were abnormally insensitive to acetylcholine but normal responsiveness was seen in a fourth case. It is proposed that CF can induce dysfunction of calcium-dependent control processes in sweat glands.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pediani, Dr John and Paton, Dr James and Bovell, Mrs Margherita
Authors: Wilson, S.M., Pediani, J., Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y., Coutts, J., Davidson, R., Lambert, J., and Morris, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities
Journal Name:Experimental Physiology
Journal Abbr.:Exp. Physiol.
ISSN:0958-0670
ISSN (Online):1469-445X

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