Wilson, S.M., Pediani, J., Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y., Coutts, J., Davidson, R., Lambert, J., and Morris, G. (1991) The cholinergic regulation of potassium (86Rb ) permeability in sweat glands isolated from patients with cystic fibrosis. Experimental Physiology, 76 (4). pp. 573-578. ISSN 0958-0670
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Publisher's URL: http://ep.physoc.org/content/76/4/573
Sweat glands isolated from skin obtained from normal subjects and patients with cystic fibrosis (CF) were pre-loaded with 86Rb+ and superfused with a physiological salt solution and the rate of 86Rb+ efflux was measured as an indicator of cellular potassium permeability. Acetylcholine always evoked a permeability increase in the glands from control subjects and this response could be resolved into calcium-dependent and calcium-independent components. Sweat glands from CF patients did not show such consistent responses. In three individuals the glands were abnormally insensitive to acetylcholine but normal responsiveness was seen in a fourth case. It is proposed that CF can induce dysfunction of calcium-dependent control processes in sweat glands.
|Glasgow Author(s):||Pediani, Dr John and Paton, Dr James and Bovell, Mrs Margherita|
|Authors:||Wilson, S.M., Pediani, J., Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y., Coutts, J., Davidson, R., Lambert, J., and Morris, G.|
|College/School:||College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities|
|Journal Name:||Experimental Physiology|
|Journal Abbr.:||Exp. Physiol.|