The cholinergic regulation of potassium (86Rb ) permeability in sweat glands isolated from patients with cystic fibrosis

Wilson, S.M., Pediani, J. , Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y. , Coutts, J., Davidson, R., Lambert, J. and Morris, G. (1991) The cholinergic regulation of potassium (86Rb ) permeability in sweat glands isolated from patients with cystic fibrosis. Experimental Physiology, 76(4), pp. 573-578.

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Publisher's URL: http://ep.physoc.org/content/76/4/573

Abstract

Sweat glands isolated from skin obtained from normal subjects and patients with cystic fibrosis (CF) were pre-loaded with 86Rb+ and superfused with a physiological salt solution and the rate of 86Rb+ efflux was measured as an indicator of cellular potassium permeability. Acetylcholine always evoked a permeability increase in the glands from control subjects and this response could be resolved into calcium-dependent and calcium-independent components. Sweat glands from CF patients did not show such consistent responses. In three individuals the glands were abnormally insensitive to acetylcholine but normal responsiveness was seen in a fourth case. It is proposed that CF can induce dysfunction of calcium-dependent control processes in sweat glands.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Paton, Dr James and Pediani, Dr John and Bovell, Mrs Margherita
Authors: Wilson, S.M., Pediani, J., Cockburn, F., Bovell, D.L., Jenkinson, D.M., Paton, J.Y., Coutts, J., Davidson, R., Lambert, J., and Morris, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Experimental Physiology
Journal Abbr.:Exp. Physiol.
ISSN:0958-0670
ISSN (Online):1469-445X

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