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Theophylline does not increase ventilatory responses to hypercapnia or hypoxia

Swaminathan, Soumya, Paton, James Y., Ward, Sally L. Davidson, Sargent, Charles W., and Keens, Thomas G. (1992) Theophylline does not increase ventilatory responses to hypercapnia or hypoxia. American Journal of Respiratory and Critical Care Medicine, 146 (6). pp. 1398-1401. ISSN 1073-449X (doi:10.1164/ajrccm/146.6.1398)

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Abstract

Theophylline is commonly believed to stimulate central respiratory centers. We studied the effect of oral theophylline therapy on ventilatory responses to hypercapnia and hypoxia during a double-blind placebo-controlled trial with a slow release oral theophylline preparation. We measured hypercapnic and hypoxic ventilatory responses using rebreathing techniques in 15 subjects (21 to 41 yr of age, with normal lung function) on three occasions: baseline, after 4 days of Drug 1, and after 4 days of Drug 2. For subjects receiving theophylline, the mean serum theophylline level was 11.3 + 1.3 (SE) µg/ml (range, 5.3 to 22.1). Unpleasant side effects were reported by 11 of the 15 subjects (nausea, jitteriness, and agitation) while receiving theophylline but not while receiving placebo. The mean hypercapnic ventilatory response with placebo was 4.3 ± 0.9 L/min/mm Hg PACO2 and with theophylline it was 4.5 ± 0.7 L/min/mm Hg PACO2. The mean hypoxic ventilatory response with placebo was −3.9 ± 1.0 L/min/%SaO2 and with theophylline it was −2.7 ± 0.4 L/min/%SAO2. Hypoxic responses for each subject were measured at similar PvCO2. There were no significant changes in ventilatory responses with theophylline. We conclude that theophylline use, at a dose sufficient to cause side effects, does not affect chemoreceptor respons

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Paton, Dr James
Authors: Swaminathan, Soumya, Paton, James Y., Ward, Sally L. Davidson, Sargent, Charles W., and Keens, Thomas G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities
Journal Name:American Journal of Respiratory and Critical Care Medicine
Journal Abbr.:Am. J. Respir. Crit. Care Med.
Publisher:American Thoracic Society
ISSN:1073-449X
ISSN (Online):1535-4970
Published Online:17 December 2012

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