IDEOM: an excel interface for analysis of LC-MS based metabolomics data

Creek, D.J., Jankevics, A., Burgess, K.E.V., Breitling, R. and Barrett, M.P. (2012) IDEOM: an excel interface for analysis of LC-MS based metabolomics data. Bioinformatics, 28(7), pp. 1048-1049. (doi:10.1093/bioinformatics/bts069) (PMID:22308147)

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Abstract

The application of emerging metabolomics technologies to the comprehensive investigation of cellular biochemistry has been limited by bottlenecks in data processing, particularly noise filtering and metabolite identification. IDEOM provides a user-friendly data processing application that automates filtering and identification of metabolite peaks, paying particular attention to common sources of noise and false identifications generated by liquid chromatography–mass spectrometry (LC-MS) platforms. Building on advanced processing tools such as mzMatch and XCMS, it allows users to run a comprehensive pipeline for data analysis and visualization from a graphical user interface within Microsoft Excel, a familiar program for most biological scientists.

IDEOM is provided free of charge at http://mzmatch.sourceforge.net/ideom.html, as a macro-enabled spreadsheet (.xlsb). Implementation requires Microsoft Excel (2007 or later). R is also required for full functionality.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Burgess, Dr Karl and Barrett, Professor Michael and Breitling, Professor Rainer and Creek, Dr Darren
Authors: Creek, D.J., Jankevics, A., Burgess, K.E.V., Breitling, R., and Barrett, M.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Bioinformatics
Publisher:Oxford University Press
ISSN:1367-4803
ISSN (Online):1460-2059
Published Online:04 February 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
371796The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOME)085349/Z/08/ZIII - PARASITOLOGY
371798The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOME)085349/B/08/ZIII - PARASITOLOGY
620261Metabolomic characterisation of clinical biofilms: monitoring of their formation and dispersal on different nanoscale patterned surfaces (ISSF Catalyst)Karl BurgessWellcome Trust (WELLCOME)097821/Z/11/ZIII - PARASITOLOGY