Disorders of blood pressure regulation — role of catecholamine biosynthesis, release, and metabolism

Currie, G. , Freel, E. M., Perry, C. G. and Dominiczak, A. F. (2012) Disorders of blood pressure regulation — role of catecholamine biosynthesis, release, and metabolism. Current Hypertension Reports, 14(1), pp. 38-45. (doi:10.1007/s11906-011-0239-2)

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Publisher's URL: http://dx.doi.org/10.1007/s11906-011-0239-2

Abstract

Catecholamines (epinephrine and norepinephrine) are synthesised and produced by the adrenal medulla and postganglionic nerve fibres of the sympathetic nervous system. It is known that essential hypertension has a significant neurogenic component, with the rise in blood pressure mediated at least in part by overactivity of the sympathetic nervous system. Moreover, novel therapeutic strategies aimed at reducing sympathetic activity show promise in the treatment of hypertension. This article reviews recent advances within this rapidly changing field, particularly focusing on the role of genetic polymorphisms within key catecholamine biosynthetic enzymes, cofactors, and storage molecules. In addition, mechanisms linking the sympathetic nervous system and other adverse cardiovascular states (obesity, insulin resistance, dyslipidaemia) are discussed, along with speculation as to how recent scientific advances may lead to the emergence of novel antihypertensive treatments.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Perry, Dr Colin and Dominiczak, Professor Anna and Currie, Dr Gemma and Freel, Dr Marie
Authors: Currie, G., Freel, E. M., Perry, C. G., and Dominiczak, A. F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Current Hypertension Reports
Publisher:Springer Healthcare
ISSN:1522-6417
ISSN (Online):1534-3111
Published Online:09 November 2011
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
496251Translational studies on the role of corticosteroids in cardiovascular diseaseMarie FreelMedical Research Council (MRC)G0802803Institute of Cardiovascular and Medical Sciences