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The effect of reconstitution with cryopreserved thymocytes on thein vivoantibody response to sheep red blood cells, Aeromonas salmonicida, and DNP-KLH, in adult long term thymectomised rainbow trout (Oncorhynchus mykiss)

Findlay, C., and Tatner, M.F. (1996) The effect of reconstitution with cryopreserved thymocytes on thein vivoantibody response to sheep red blood cells, Aeromonas salmonicida, and DNP-KLH, in adult long term thymectomised rainbow trout (Oncorhynchus mykiss). Fish and Shellfish Immunology, 6 (5). pp. 371-381. ISSN 1050-4648 (doi:10.1006/fsim.1996.0037)

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Abstract

The effect of long term adult thymectomy, and subsequent reconstitution with autogenic cryopreserved thymocytes, on thein vivoantibody response to the thymus dependent (TD) antigens (DNP-KLH and SRBC) and thymus independent (TI) antigen (A. salmonicida) was examined in rainbow trout,Oncorhynchus mykiss. Thymectomy eight months prior to primary immunis-ation led to a reduced secondary response to SRBC and DNP-KLH, which was partly restored when the fish were reconstituted with their own cryopreserved thymocytes one week before secondary immunisation. In contrast eight month thymectomy produced an elevated secondary antibody response toA. salmonicida. This again was partly returned to control levels by reconstitution with the fish's autogenic cryopreserved thymocytes one week prior to secondary immunisation. The data provide evidence for a T-helper cell population, involved in the memory response to TD antigens, and for T-suppressor cell activity to TI antigens.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Tatner, Dr Mary
Authors: Findlay, C., and Tatner, M.F.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Fish and Shellfish Immunology
ISSN:1050-4648
ISSN (Online):1095-9947
Published Online:22 April 2002

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