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Abnormal control of ventilation in adolescents with myelodysplasia

Swaminathan, S., Paton, J.Y., Ward, S.L., Jacobs, R.A., Sargent, C.W., and Keens, T.G. (1989) Abnormal control of ventilation in adolescents with myelodysplasia. Journal of Pediatrics, 115 (6). pp. 898-903. ISSN 0022-3476

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Abstract

Infants with myelomeningocele have abnormalities in ventilatory control. To determine whether these persist into later life, we studied 14 patients with myelomeningocele and Arnold-Chiari malformation (age 18.0 +/- 0.8 (SE) years), and compared them with 14 control subjects (age 24.0 +/- 0.9 years). Pulmonary function and ventilatory muscle strength did not differ between patients with myelomeningocele and control subjects. Hypercapnic ventilatory responses were significantly lower in the group with myelomeningocele (1.98 L/min/mm Hg) compared with control values (3.33 L/min/mm Hg; p less than 0.01). Hypoxic ventilatory responses (-1.4 L/min/%oxygen saturation of hemoglobin in arterial blood) were not significantly different from control values (-2.14 L/min/%oxygen saturation). In control subjects the hypercapnic and hypoxic ventilatory responses were highly correlated with each other within subjects (r = 0.84; p less than 0.002) but not in those with myelomeningocele (r = 0.34; not significant). We concluded that adolescents and young adults with myelomeningocele have abnormalities in control of ventilation during sleep and wakefulness. We speculate that the Arnold-Chiari malformation interferes with central chemosensitivity (hypercapnic ventilatory response) and central integration of chemoreceptor output.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Paton, Dr James
Authors: Swaminathan, S., Paton, J.Y., Ward, S.L., Jacobs, R.A., Sargent, C.W., and Keens, T.G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities
Journal Name:Journal of Pediatrics
Journal Abbr.:J Pediatr.
ISSN:0022-3476
ISSN (Online):1097-6833
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